Treatment of experimental heart failure with hepatocyte growth factor
نویسندگان
چکیده
منابع مشابه
Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure.
BACKGROUND Despite advances in surgical and percutaneous coronary revascularization, ongoing ischemia that is not amenable to standard revascularization techniques is a major cause of morbidity and mortality. Hepatocyte Growth Factor (HGF) has potent angiogenic and anti-apoptotic activities, and this study evaluated the functional and biochemical effects of HGF gene transfer in a rat model of p...
متن کاملEarly treatment with hepatocyte growth factor improves cardiac function in experimental heart failure induced by myocardial infarction.
Plasma levels of hepatocyte growth factor (HGF) are increased within hours of cardiac ischemia/reperfusion in rats, and HGF has been shown to be cardioprotective toward acute ischemic injury. Myocardial levels of HGF mRNA and protein are increased for several days after myocardial infarction (MI), however, indicating a possible additional protective effect of HGF toward the progression of MI to...
متن کاملAngiotensin-converting enzyme inhibition restores hepatocyte growth factor production in patients with congestive heart failure.
Endothelium-dependent vasodilation is impaired in patients with congestive heart failure. For vascular endothelium, hepatocyte growth factor (HGF) is one of the most potent and specific growth factors, which acts protectively against endothelial dysfunction. HGF production is downregulated by angiotensin II (Ang II) in vitro. We hypothesized that HGF production is impaired as the result of incr...
متن کامل[Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty].
BACKGROUND We hypothesized that transfection of the gene for human hepatocyte growth factor(hHGF) combined with cellular cardiomyoplasty might regenerate the impaired myocardium. METHODS AND RESULTS We used a ligation model of proximal left anterior descending coronary artery of Lewis rats. Two weeks after left anterior descending coronary artery ligation, three different treatments were cond...
متن کاملEstablishment of human hair follicle mesenchymal stem cells with overexpressed human hepatocyte growth factor
Objective(s): Chronic liver disease has become a major health problem that causes serious damage to human health. Since the existing treatment effect was not ideal, we need to seek new treatment methods. Materials and Methods: We utilized the gene recombination technology to obtain the human hair mesenchymal stem cells which overexpression of human hepatocyte growth factor (hHGF). Furthermore, ...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2003
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(03)82899-1